Methyl p-nitrophenylacetate Property

Melting point:

52.4-53.3 °C

Boiling point:

308.6±17.0 °C(Predicted)

Density 

1.266±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

Off-white

Safety

HS Code 

2915390090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Methyl p-nitrophenylacetate Chemical Properties,Usage,Production

Appearance

a pale orange oil

Synthesis

4-nitrophenylacetic acid(2.00 g, 11 mmol) was added to a clean carousel tube. Dimethyl carbonate (3 mL, 3.21 g, 35.6 mmol) was added, and the reaction was heated at reflux overnight. The brown solution was allowed to cool, and poured in to aqueous sodium bicarbonate (10%, 10 mL) while stirring. The resulting mixture was extracted with ethyl acetate (3 x 10 mL). The combined organic layers were washed with water and brine (10 mL each), and dried over anhydrous magnesium sulphate. After filtration and evaporation of the solvents, proton NMR analysis showed the product had formed, and none of the precursor acid remained. No further purification was performed. This gave methyl p-nitrophenylacetate as a pale orange oil (1.929 g, 9.89 mmol, 90%)): 1H NMR (400 MHz, CDCl 3 ) |? 8.20 (d, J = 8.6 Hz, 2H), 7.46 (d, J = 8.6 Hz, 2H, 3.74 (s, 2H), 3.73 (s, 3H).